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. Author manuscript; available in PMC: 2018 Feb 13.
Published in final edited form as: Adv Healthc Mater. 2015 Mar 13;5(1):10–55. doi: 10.1002/adhm.201400842

Figure 10.

Figure 10

Engineering mesenchymal stem cells with angiogenin to enhance cardiac repair. Effects of angiogenin modified MSC transplantation on heart remodeling. A) Transverse sections of hearts treated with MSC-AdANG, with MSC-AdEGFP, and with PBS were HE stained. C) Smaller infarct sizes and D) LV chamber sizes as well as E) thicker border-zone walls were seen in the post-MI heart treated with MSC-AdANG compared with control hearts. Collagen in the infarct areas was shown by VG staining. B,F) Positively stained fibrous infarct areas were clearly observed in the PBS group, and not obviously reduced in MSC-AdEGFP group, but significantly reduced in MSC-AdANG group. Reproduced with permission.[215] Copyright 2008, Elsevier.