Table 4.
Comparison of preference of antipsychotics in the Korean Medication Algorithm for Depressive Disorder
| Preference of atypical antipsychotics | Third revision (2017) | Second revision (2012) | First revision (2006) (when using AP) | ||
|---|---|---|---|---|---|
|
|
|
||||
| Non-psychotic | Psychotic | Non-psychotic | Psychotic | ||
| Amisulpride | 5.0 (4.6–5.5) | 6.0 (5.6–6.3) | 5.5 (5.0–5.9) | 6.6 (6.1–7.0) | 5.8 (5.3–6.2) |
| Aripiprazole | 8.3 (8.2–8.5)*,† | 8.3 (8.1–8.5)* | 7.9 (7.6–8.2)* | 7.9 (7.6–8.2)* | 6.3 (5.8–6.7) |
| Blonanserin | 4.6 (4.2–5.0) | 6.1 (5.7–6.5) | 4.4 (3.7–5.1) | 5.8 (5.1–6.4) | - |
| Clozapine | 2.7 (2.3–3.1) | 3.9 (3.4–4.3) | 2.9 (2.4–3.4) | 4.1 (3.6–4.6) | 3.5 (3.0–4.0) |
| Olanzapine | 6.0 (5.6–6.4) | 7.3 (7.0–7.7)* | 6.6 (6.2–7.0) | 7.6 (7.3–7.9)* | 7.1 (6.7–7.5)* |
| Paliperidone | 4.5 (4.1–5.0) | 6.9 (5.6–6.5) | - | - | - |
| Quetiapine | 7.8 (7.6–8.0)* | 7.9 (7.7–8.1)* | 7.7 (7.4–8.0)* | 8.1 (7.8–8.3)* | 7.3 (6.9–7.7)* |
| Risperidone | 5.3 (4.8–5.7) | 6.7 (6.3–7.1) | 6.0 (5.5–6.4) | 7.3 (6.9–7.6)* | 7.3 (6.9–7.7)* |
| Ziprasidone | 5.1 (4.6–5.6) | 5.9 (5.6–6.3) | 5.7 (5.2–6.3) | 6.5 (6.1–6.9) | 6.5 (6.0–6.9) |
| Typical antipsychotics | 2.9 (2.5–3.3) | 4.0 (3.4–4.3) | 3.2 (2.8–3.6) | 4.5 (4.0–5.0) | 4.8 (4.3–5.3) |
Values are presented as mean (95% confidence interval). AP, antipsychotics.
*
First-line drug maximum score of preference is 9 points.
†
Treatment of choice, defined as an option that was rated at 9 points by 50% or more of the experts.