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. 2017 Apr 19;8(8):1683–1694. doi: 10.1080/21505594.2017.1307485

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© 2017 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Decreased proinflammatory pulmonary and systemic cytokine levels in rapid DNA tattoo-vaccinated mice during experimental intranasal melioidosis. Mice were given rapid tattoo vaccination at t = 0, 3 and 6 days followed by intranasal bacterial challenge (200 CFU B. pseudomallei) on day 21. Mice were sacrificed 72 hours after intranasal B. pseudomallei challenge and heparinized blood plasma and lung homogenates were obtained. TNFα (A), IL-6 (B) and CXCL1 (C) were measured in lung homogenate; TNFα (D), IL-6 (E) and IFNγ (F) were measured in plasma. Values are in pg/mL; data are presented as box- and whisker plots showing the smallest observation, lower quartile, median, upper quartile and largest observation. N = 8 mice per group. Vaccinated groups were compared to the control group (empty pVAX) using a Mann Whitney test. *p < 0.05, **p < 0.01, ***p < 0.001.