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. 2017 Jul 13;8(8):1631–1642. doi: 10.1080/21505594.2017.1341021

Figure 1.

Figure 1.

MUC1 controls pneumococcal levels in the lungs and blood of S. pneumoniae infected mice. Wildtype (WT) and Muc1−/− mice were infected intranasally with S. pneumoniae D39 strain. Pneumococcal levels were determined 16 hours (A, B, C and D) and 1 hour (E) after infection by colony-forming assay. (A) No significance difference in S. pneumoniae loads in the nasopharynx of WT and Muc1−/− mice. (B) Muc1−/− display significantly higher levels of S. pneumoniae in the lungs as compared with WT mice; data pooled from 2 independent experiments (***p < 0.001, 2-tailed Student's t-test) (C) S. pneumoniae detected in the broncho-alveolar lavage fluid (BALF) from infected WT and Muc1−/− mice. (D) A significantly higher number of S. pneumoniae-infected Muc1−/− mice developed bacteremia as compared with infected WT mice; data pooled from 3 independent experiments (#p < 0.05, Fisher's exact test). (E) After 1 hour of infection, similar levels of pneumococci were recovered from the lungs of WT and Muc1−/− mice. Graphs present individual mice (points) and group medians (horizontal bar). The limit of detection (LD, 100 CFU/ml) is shown as a dotted line. BALF- broncho-alveolar lavage fluid.