Skip to main content
. 2017 Jul 13;8(8):1631–1642. doi: 10.1080/21505594.2017.1341021

Figure 2.

Figure 2.

Knockdown of MUC1 expression is associated with reduced pneumococcal adherence to A549 cells. (A) MUC1 Expression in wildtype (WT) and mutated clone (MUC1 clone) of A549 cells was quantified using qPCR. There was nearly 75% knockdown of MUC1 expression in MUC1 clone as compared with WT. (B) WT and MUC1 clone of A549 cells (n = 5) were co-cultured with S. pneumoniae D39 strain at a multiplicity of infection of 50: 1 and adherence assessed following 1, 2 and 6 hours of incubation. MUC1 knockdown in A549 cells lead to significantly lower binding of pneumococci (*p < 0.05, **p < 0.01, Student's t-test).