Figure 5.

MUC1 deficiency is associated with elevated inflammatory cytokines responses in the lungs during S. pneumoniae infections. Cytokine levels from lung homogenates of wildtype (WT) and Muc1^−/− mice (n = 13–14) infected with S. pneumoniae D39 strains for 16 hours were measured by ELISA. Infected Muc1^−/− mice produced significantly higher amounts of all pro-inflammatory cytokines assayed, as compared with uninfected Muc1^−/− mice (*p < 0.05, **p < 0.01,Student's t-test). Graphs present the median (horizontal bar), interquartile range (box) and 10th and 90th percentiles (bars). Uninf, uninfected; Inf, infected.