Figure 2.

C. albicans' response to the surrounding environment. A. Virulence factors attributable to host tissue damage. Op, opaque; C, cavities. B. Regulation of morphogenesis by varied environmental stimuli. Proteins are colored as follows: white, environmental sensors; gray, transcription regulators; dark gray, protein kinases; black, other genes. a, conditions required for the activation of opaque cell filamentation; b, interactions during the regulation of opaque cell filamentation; c, interactions during the regulation of the response to high cell density. HSG's, hyphal-specific genes; OpSG's, opaque-specific genes. Kinase modules are indicated as follows: MAPKK, MAPK kinase; MAPKKK, MAPKK kinase; PAK, p21-activated kinase. Black arrows indicate signal flow. T-shaped bars indicate inhibition.