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. 2018 Feb 9;11:757–767. doi: 10.2147/OTT.S155065

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© 2018 Shi et al. This work is published and licensed by Dove Medical Press Limited

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Raptor interference enhanced the inhibitory effect of cardamonin on the lysosomal localization of mTOR.

Notes: Both normal and Raptor siRNA SKOV3 cells were treated with cardamonin (5 and 20 μM) for 150 min. The lysosomal localization of mTOR was determined by immunofluorescence assays. (A) Images of SKOV3 cells coimmunostained for mTOR (green), LAMP2 (red), and nucleus (blue). (B) Quantitation of the colocalization. n=3; **P<0.01 vs SKOV3 control group; ^#P<0.05, ^##P<0.05 vs Raptor siRNA SKOV3 control group.

Abbreviations: mTOR, mammalian target of rapamycin; siRNA, small interfering RNA.