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MDM2 regulation by the DNA damage kinases. MDM2 is phosphorylated at multiple sites by DNA damage kinases, ATM, ATR, and DNA-PK. These kinases can also phosphorylate MDM2 indirectly via their downstream effectors. CK1δ is phosphorylated by ATM and targets MDM2 for degradation by β-TrCP. See text for more details.
