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. Author manuscript; available in PMC: 2018 Feb 13.
Published in final edited form as: J Cell Physiol. 2015 Oct;230(10):2318–2327. doi: 10.1002/jcp.24994

Fig. 5.

Fig. 5

Ubiquitination and ubiquitin-like modifications of MDM2 (A) The E3 ligases SCFβ-TRCP, APC/C, PCAF, and MDM2 itself can attach K48 ubiquitin chains to MDM2, which mark it for proteasomal degradation. Ubiquitination of MDM2 is inhibited by the deubiquitinating enzymes HAUSP, USP2a, and USP15 as well as by the process of SUMOylation and NEDDylation. (B) NEDD4-1 attaches a K63 ubiquitin chain to MDM2, which does not mark it for degradation but does prevent the attachment of K48 ubiquitin chains and enhances MDM2 stability.