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. Author manuscript; available in PMC: 2018 Feb 13.
Published in final edited form as: J Neuroimmunol. 2012 Feb 18;245(1-2):8–14. doi: 10.1016/j.jneuroim.2012.01.007

Figure 4. Analysis of blood-brain barrier permeability in EAE.

Figure 4

Evans blue dye was injected IP and 1 hr later tissues were collected from the brain (A) and spinal cord (B) after perfusion with PBS. Quantification of dye extracted from the tissue showed increased levels in mice sensitized for EAE compared with naive (no EAE) WT, and in animals with EAE higher levels of dye in spinal cord (B) compared with brain (A). However no significant differences were noted between genotypes. C, typical distribution of dye in the brain and spinal cord is shown.