TABLE I. EAE in Cx43 and Cx30 deficient mice.
Genotype | n | AUCa | Peak Score | Date of Onset | Date of Peak Score | Incidence (%) | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SE | Mean | SE | Mean | SE | Mean | SE | Mean | SE | ||
WT | 27 | 16.8 | 1.4 | 2.5 | 0.1 | 12.6 | 0.5 | 15.1 | 0.6 | 81.6 | 4.4 |
Cx43F/F Cx30+/+ | 21 | 18.0 | 1.8 | 2.8 | 0.1 | 12.7 | 0.7 | 15.4 | 0.8 | 91.6 | 5.3 |
Cre Cx43F/F (sKO) | 26 | 19.7 | 1.1 | 3.0 | 0.1 | 12.6 | 0.5 | 15.3 | 0.5 | 91.6 | 5.2 |
Cx43F/F Cx30−/− | 10 | 13.2 | 1.2 | 2.3 | 0.2 | 12.7 | 0.7 | 16.9 | 1.0 | 100.0 | 5.2 |
Cre Cx43F/F Cx30−/− (dKO) | 16 | 16.8 | 1.9 | 2.7 | 0.2 | 12.6 | 0.5 | 15.8 | 0.7 | 83.6 | 7.5 |
Area under the curve (AUC) was calculated for days 10-25. Animals were excluded from analysis which did not attain a clinical score of at least 1 for two consecutive days, or which died or were sacrificed before 25 days post immunization. n, number of animals per group included in analysis. SE, standard error.