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. 2018 Jan 17;30(1):134–152. doi: 10.1105/tpc.17.00626

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Figure 10. — A Working Model for Canonical and Noncanonical Mechanisms of HD2C and HD2B in rRNA Processing.

HD2C and HD2B form complex and drive pre-rRNA processing and ribosome biogenesis via a canonical and/or noncanonical pathway. On the one hand, HD2C and HD2B directly bind and repress the expression of key genes required for ribosome biogenesis, including ribosome biogenesis proteins (e.g., PRMT3 and/or NUC1) and snoRNAs (e.g., U14). On the other hand, HD2C and HD2B are associated with pre-rRNA and snoRNAs to regulate rRNA modifications (e.g., methylation) and pre-rRNA processing.