Table 2.
Outcomes Associated With Parenteral Anticoagulation of Atrial Fibrillation During Sepsis
| Analysis | No. (%) | RR (95% CI) | |
|---|---|---|---|
| Anticoagulation | No Anticoagulation | ||
| Unadjusted | |||
| Ischemic stroke | 174/13 611 (1.3) | 341/24 971 (1.4) | 0.94 (0.78–1.12) |
| Bleeding | 1174/13 611 (8.6) | 1773/24 971 (7.1) | 1.24 (1.13–1.36) |
| Primary analysis: Propensity score matcheda | |||
| Ischemic stroke | 174/13 505 (1.3) | 185/13 505 (1.4) | 0.94 (0.77–1.15) |
| Bleeding | 1163/13 505 (8.6) | 979/13 505 (7.2) | 1.21 (1.10–1.32) |
Abbreviation: RR, relative risk.
Propensity score models used to match patients or produce inverse probability of treatment weights included the following variables: age, sex, race, hospital teaching status, hospital geographical location, attending physician specialty, presence of preexisting or newly diagnosed atrial fibrillation, prior stroke, prior bleeding, intensive care, history of heart failure, diabetes, hypertension, coronary artery disease, chronic kidney disease, chronic lung disease, valvular heart disease, peripheral vascular disease, cancer, dementia, acute respiratory failure, acute renal failure, acute circulatory failure, acute neurologic failure, acute hematologic failure, acute hepatic failure, acidosis, source of infection, use of vasopressors, and year of hospitalization. Propensity scores matched 13 505 of 13 611 (99.2%) patients who received anticoagulation, including all patients receiving anticoagulation who experienced stroke, with 13 505 of 24 971 (54.1%) patients who did not receive anticoagulation.