Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
General structure of chimeric antigen receptor.
The second generation chimeric antigen receptor (pictured) comprises three primary components: a single chain variable fragment (scFV) that recognizes a specific tumor antigen (e.g., HER2), an intracellular co-stimulatory domain (commonly CD28), and the intracellular CD3ζ chain. Third generation CARs may have a second co-stimulatory domain between the second generation co-stimulatory domain and the CD3ζ chain (typically 4-1BBB or OX40).
