Table 2.
Associations between urine cotinine levels, DNA methylation, and cis-gene expression in CD14+ monocytes.
| Urine cotinine ∼ Methylation |
Methylation ∼ cis Gene expression |
Urine Cotinine ∼ Gene expression |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CpG ID (location) | Chr | Cor | P value | FDR | Gene | Cor | P value | FDR | Cor | P value | FDR |
| cg12075928 (PTK2 Body) | 8 | −0.22 | 1.64E-11 | 2.24E-07 | PTK2 | 0.13 | 6.74E-06 | 1.59E-03 | −0.12 | 5.74E-04 | 0.08 |
| cg20066188 (CYTH4 Body) | 22 | −0.18 | 7.54E-08 | 4.19E-04 | NCF4 | −0.12 | 2.00E-05 | 4.04E-03 | 0.10 | 3.50E-03 | 0.18 |
| cg12513616 (LOC100128340 body) | 5 | −0.20 | 4.55E-10 | 4.79E-06 | PDLIM7 | −0.12 | 1.21E-05 | 2.63E-03 | 0.10 | 4.30E-03 | 0.20 |
| cg13300301 (FUT4 1stExon) | 11 | 0.16 | 1.45E-06 | 4.54E-03 | PIWIL4 | −0.16 | 4.88E-09 | 2.32E-06 | −0.10 | 4.73E-03 | 0.20 |
| cg02186444 (ARMC7 Body) | 17 | 0.21 | 1.32E-10 | 1.70E-06 | NT5C | −0.21 | 4.71E-14 | 4.07E-11 | −0.09 | 0.01 | 0.29 |
CpGs whose degree of methylation significantly associated with urine cotinine levels in CD14+ monocyte samples (n = 930, FDR<0.01), and cis-gene expression (n = 1,264, genes ±1 MB; FDR<0.01), with urine cotinine associations also associated with gene expression in CD14+ monocyte samples (n = 934, P<0.05). Results are sorted by significance of urine cotinine and gene expression. Partial correlations (cor) were adjusted for age, sex, race, study site, and residual contamination with non-targeted cells.