Table 2.

DNA methylation of mitochondrial-encoded genes in the rat brain following morphine induction.

Region	Treatment	Mtco1	Mtco2	Mtco3
Cerebellum	Control	2.1 (0.1)	0.9 (0.1)	1.1 (0.1)
	Acute	2.0 (0.2)	1.0 (0.1)	1.2 (0.1)
	Chronic	2.1 (0.1)	0.9 (0.1)	1.1 (0.1)
Cerebral cortex	Control	2.7 (0.6)	0.8 (0.1)	1.1 (0.1)
	Acute	1.8 (0.3)	0.9 (0.2)	1.1 (<0.01)
	Chronic	1.9 (0.4)	0.8 (0.1)	1 (0.1)
Hippocampus	Control	1.9 (0.1)	1.0 (0.1)	1.2 (0.1)
	Acute	1.9 (0.2)	0.8 (0.1)	1.3 (0.1)
	Chronic	1.8 (0.1)	0.8 (0.1)	1.1 (0.1)
Hypothalamus	Control	2.0 (0.1)	0.9 (0.1)	1.1 (0.1)
	Acute	2.1 (0.2)	0.9 (0.1)	1.1 (0.1)
	Chronic	1.9 (0.2)	0.7 (0.1)	1.0 (0.1)
Inferior colliculus	Control	2.2 (0.1)	1.0 (0.1)	1.3 (0.2)
	Acute	2.2 (0.1)	0.9 (0.1)	1.2 (0.1)
	Chronic	2.0 (0.1)	0.8 (0.1)	1.1 (0.1)
Medulla oblongata	Control	2.4 (0.3)	1.0 (0.1)	1.1 (0.1)
	Acute	2.0 (0.2)	0.8 (0.1)	1.1 (0.1)
	Chronic	2.0 (0.2)	0.8 (0.1)	1.1 (0.1)
Midbrain	Control	1.9 (0.2)	0.9 (0.1)	1.2 (0.2)
	Acute	2.2 (0.4)	0.9 (0.1)	1.1 (0.1)
	Chronic	2.0 (0.2)	1.0 (0.1)	1.1 (0.1)
Pons	Control	1.9 (0.3)	0.8 (0.1)	1.0 (0.2)
	Acute	2.3 (0.4)	0.8 (0.1)	1.6 (0.5)
	Chronic	2.6 (1.0)	0.8 (0.1)	1.1 (0.1)
Superior colliculus	Control	2.1 (0.1)	1.0 (0.1)	1.3 (0.1)
	Acute	2.4 (0.2)	0.8 (0.1)	1.3 (<0.01)
	Chronic	2.1 (0.2)	0.9 (0.1)	1.3 (0.1)
Thalamus	Control	2.1 (0.1)	1.0 (0.1)	1.3 (0.2)
	Acute	1.9 (0.1)	0.9 (0.1)	1.1 (<0.01)
	Chronic	1.8 (0.2)	1.0 (0.3)	0.9 (0.1)

Mean DNA methylation levels of three genes (Mtco1, Mtco2, and Mtco3) are provided, with standard error of the mean in brackets.