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. Author manuscript; available in PMC: 2018 Feb 13.
Published in final edited form as: Pharmacol Biochem Behav. 2016 Jan 2;142:79–84. doi: 10.1016/j.pbb.2015.12.010

Figure 1. Design of the intermittent delivery device.

Figure 1

A: Coils measuring 190 cm in length were filled with alternating 2.5-μl infusions of nicotine solution and oil. B: Filled coils were attached to primed osmotic minipumps, and glue was used to attach the flow moderator cap to the pump (1) and the coil to the cap/flow moderator (2). A piece of heat-shrink tubing was then placed over the flow moderator (3) and sealed. C: The completed device measured less than 7 cm in length and fit comfortably in the IP cavity of a rat weighing ≥ 350 g.