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. Author manuscript; available in PMC: 2018 Feb 13.
Published in final edited form as: Pharmacol Biochem Behav. 2016 Jan 2;142:79–84. doi: 10.1016/j.pbb.2015.12.010

Figure 3. Effect of administration method on dependence score.

Figure 3

Figure 3

Rats were treated for 14 days with 1.2 (A), 2.4 (B), or 4.8 (C) mg/kg/d nicotine administered either continuously or every other hour via osmotic minipump. Mean counts of somatic withdrawal signs were summed across 50-min observation periods following a 1.5 mg/kg SC mecamylamine challenge. Animals receiving 1.2 mg/kg/d nicotine intermittently scored significantly higher (p ≤ 0.03) than saline controls at days 7, 14, and 21 (A). Animals receiving 2.4 mg/kg/d nicotine intermittently scored significantly higher than saline controls at days 7, 14, 21, and 28, and significantly higher than continuously-treated animals at days 7, 21, and 28. Intermittently-treated animals receiving 4.8 mg/kg/d scored significantly higher (p ≤ 0.05) than saline controls at days 7, 14, and 21; additionally, they scored significantly higher than continuously-treated animals at day 21. Continuously-treated animals scored significantly higher than saline controls at day 14. * denotes intermittent groups that scored significantly higher than saline; # denotes intermittent groups that scored significantly higher than continuous groups. Error bars represent SEM.