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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Curr Opin Rheumatol. 2018 Jan;30(1):129–135. doi: 10.1097/BOR.0000000000000454

Figure 2. The effect of EV from IL-1β stimulated synovial fibroblasts on normal articular chondrocytes.

Figure 2

Articular chondrocytes were treated with fresh-DMEM, exosomes from non-stimulated synovial fibroblasts (SFB) or exosomes from IL-1β stimulated SFB. The expression of OA-related genes was analyzed by real-time PCR. MMP-13 was significantly up-regulated, and ACAN was significantly down-regulated by exosomes from IL-1β stimulated SFB. **P < 0.01 versus Exo -IL. MD; fresh-DMEM with 10% FBS, Exo -IL; exosomes from non-stimulated SFB, Exo + IL; exosomes from IL-1β stimulated SFB.