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. 2018 Feb 13;13(2):e0192769. doi: 10.1371/journal.pone.0192769

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© 2018 de Cesar Netto et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — (A) Hematoxylin-Eosin, 40x. Control Group: cell morphology slightly altered, well delimited collagen bundles, minimal increase in cellularity, no changes in vascularization or ground substance. (B) HD Group: increased cellularity, altered cellular morphology with greater roundness of the cellular nuclei, loss of the wavy pattern of collagen bundles and areas of neovascularization (black arrows). (C) LD Group: Areas of increased, decreased and acellularity, destruction of collagen bundle architecture, increased number vascular clusters (black arrows) loss of collagen bundle architecture (D) LD Group: diffuse increase of the ground substance, altered cellular morphology, rounding of cell nuclei with halo formation, compatible with chondroid metaplasia (white arrows).