Table 1. Comparison of vascular and metabolic parameters between the control and treated groups at each time point and comparison of each parameter between time points in each group.
| Control (n = 8) | P value | Treated (n = 10) | P value | P value | |||
|---|---|---|---|---|---|---|---|
| 4 Hours | 1 Week | 4 Hours | 1 Week | ||||
| Ktrans (min-1) | time × group: 0.023 | ||||||
| Baseline | 0.29 ± 0.13 | 0.137 | 0.049 | 0.28 ± 0.69 | <0.001 | 0.001 | 0.816 |
| 4 Hours | 0.26 ± 0.08 | 0.062 | 0.16 ± 0.05 | 0.081 | 0.055 | ||
| 1 Week | 0.19 ± 0.06 | 0.20 ± 0.07 | 0.903 | ||||
| iAUC (mmol/sec) | time × group: <0.001 | ||||||
| Baseline | 27.85 ± 10.39 | 0.853 | 0.037 | 26.49 ± 5.82 | <0.001 | 0.024 | 0.819 |
| 4 Hours | 28.31 ± 8.30 | 0.014 | 12.95 ± 5.44 | <0.001 | 0.015 | ||
| 1 Week | 18.58 ± 5.22 | 21.23 ± 7.76 | 0.555 | ||||
| SUVmax | time × group: 0.143 | ||||||
| Baseline | 8.72 ± 2.91 | NA | NA | 6.44 ± 2.00 | NA | NA | NA |
| 4 Hours | 6.91 ± 3.01 | NA | 5.77 ± 1.80 | NA | NA | ||
| 1 Week | 8.79 ± 2.70 | 5.52 ± 2.59 | NA | ||||
| SUVmean | time × group: 0.237 | ||||||
| Baseline | 5.50 ± 2.02 | NA | NA | 4.00± 1.22 | NA | NA | NA |
| 4 Hours | 4.37 ± 1.91 | NA | 3.50 ± 1.14 | NA | NA | ||
| 1 Week | 5.21 ± 1.59 | 3.19 ± 1.56 | NA | ||||
| MTV (cm3) | time × group: 0.001 | ||||||
| Baseline | 3.78 ± 2.01 | 0.018 | <0.001 | 2.81 ± 1.09 | 0.038 | <0.001 | 0.374 |
| 4 Hours | 4.65 ± 2.00 | <0.001 | 3.66 ± 0.91 | 0.005 | 0.345 | ||
| 1 Week | 10.69± 4.02 | 6.09 ± 2.17 | 0.035 | ||||
| TLG | time × group: <0.001 | ||||||
| Baseline | 23.96 ± 21.28 | 0.627 | 0.001 | 10.66 ±3.64 | 0.341 | 0.066 | 0.225 |
| 4 Hours | 21.67 ± 13.47 | 0.001 | 12.41 ± 4.33 | 0.126 | 0.193 | ||
| 1 Week | 60.23 ± 35.20 | 18.93 ± 12.85 | 0.035 | ||||
Data are presented as mean ± standard deviation
Ktrans: volume transfer coefficient
iAUC: initial area under the gadolinium concentration-time curve until 60 seconds
SUV: standardized uptake value
MTV: metabolic tumor volume
TLG: total lesion glycolysis