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. 2014 Nov 28;6(2):1394–1398. doi: 10.1039/c4sc03117b

Table 1. Screening of different Ligands.

Inline graphic
Entry a [Pd] Ligand Conv. (%) 2a : 3 : 4 b
1 Pd[P(t-Bu)3]2 Full 44 : 56 : 0
2 Pd2(dba)3 L1, SPhos 46 83 : 0 : 17
3 Pd2(dba)3 L2, CPhos 38 87 : 0 : 13
4 Pd2(dba)3 L3, XPhos Full >99 : 0 : 0
5 Pd-PEPPSI-IPent Full 96 : 0 : 4

aConditions: (3-methylbut-2-en-2-yl)lithium (0.40 mmol, 0.6 M in THF) was added to a solution of 1a (0.3 mmol) and catalyst in toluene (1 mL), 1 h addition time.

b 2a : 3 : 4 ratios determined by GC analysis. dba = dibenzylideneacetone.