Fig. 1. Biosynthesis of zeamine II (1). (A) Domain and module organization of Zmn10–14 which constitute a type I iterative FAS/PKS showing high homology to PUFA synthases. (B) Proposed biosynthetic scheme for zeamine II. Domains are abbreviated as follows: KS = ketosynthase, KR = ketoreductase, ACP = acyl carrier protein, CLF = chain length factor, TR = thioester reductase, DH = dehydratase, ER = enoyl reductase, AMT = aminotransferase.