Table 2.
Multivariate logistic regression for the presence of bone metastasis in patients with breast cancer
| Characteristics | Patients, no. (%)
|
In the entire cohorta
|
Among initial MBC patientsa
|
|||
|---|---|---|---|---|---|---|
| Entire cohort (n=245,707) |
With bone metastasis (n=8901) |
OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Age, years | ||||||
| 18–40 | 13,920 (5.7) | 613 (6.9) | 1 (Reference) | NA | 1 (Reference) | NA |
| 41–60 | 100,422 (40.9) | 3534 (39.7) | 0.977 (0.889–1.073) | 0.629 | 0.924 (0.794–1.075) | 0.306 |
| 61–80 | 106,504 (43.3) | 3758 (42.2) | 1.056 (0.961–1.162) | 0.258 | 0.831 (0.713–0.969) | 0.018 |
| >80 | 24,861 (10.1) | 996 (11.2) | 0.798 (0.711–0.895) | <0.001 | 0.624 (0.522–0.746) | <0.001 |
| Sex | ||||||
| Female | 243,786 (99.2) | 8800 (98.9) | 1 (Reference) | NA | 1 (Reference) | NA |
| Male | 1921 (0.8) | 101 (1.1) | 0.956 (0.766–1.193) | 0.69 | 0.996 (0.704–1.411) | 0.984 |
| Marital status | ||||||
| Married | 130,200 (53) | 3778 (42.5) | 1 (Reference) | NA | 1 (Reference) | NA |
| Unmarried | 100,495 (40.9) | 4631 (52) | 1.285 (1.223–1.350) | <0.001 | 1.086 (1.005–1.174) | 0.038 |
| Unknown | 15,012 (6.1) | 492 (5.5) | 0.891 (0.802–0.989) | 0.031 | 0.970 (0.826–1.138) | 0.704 |
| Race | ||||||
| White | 195,472 (79.6) | 6914 (77.7) | 1 (Reference) | NA | 1 (Reference) | NA |
| Black | 27,193 (11.1) | 1353 (15.2) | 0.980 (0.915–1.048) | 0.548 | 0.749 (0.678–0.827) | <0.001 |
| Otherb | 21,393 (8.7) | 601 (6.8) | 0.748 (0.682-0.819) | <0.001 | 0.809 (0.701–0.933) | 0.004 |
| Unknown | 1649 (0.6) | 33 (0.3) | 0.451 (0.313–0.651) | <0.001 | 0.863 (0.485–1.536) | 0.618 |
| Hispanic origin | ||||||
| Yes | 26,247 (10.7) | 919 (10.3) | 1 (Reference) | NA | 1 (Reference) | NA |
| No | 219,460 (89.3) | 7982 (89.7) | 1.256 (1.163–1.356) | <0.001 | 1.185 (1.052–1.335) | 0.005 |
| Tumor grade | ||||||
| Grade I | 51,978 (21.2) | 620 (7) | 1 (Reference) | NA | 1 (Reference) | NA |
| Grade II | 100,106 (40.7) | 3107 (34.9) | 1.582 (1.444–1.732) | <0.001 | 1.159 (0.981–1.368) | 0.082 |
| Grade III | 74,259 (30.2) | 2793 (31.4) | 1.341 (1.218–1.476) | <0.001 | 0.694 (0.588–0.820) | <0.001 |
| Unknown | 19,364 (7.9) | 2381 (26.7) | 3.066 (2.765–3.401) | <0.001 | 0.957 (0.806–1.137) | 0.62 |
| Laterality | ||||||
| Right | 119,979 (48.8) | 4127 (46.4) | 1 (Reference) | NA | 1 (Reference) | NA |
| Left | 124,036 (50.5) | 4292 (48.2) | 0.998 (0.953–1.046) | 0.946 | 0.985 (0.914–1.061) | 0.69 |
| Unknown | 1692 (0.7) | 482 (5.4) | 3.071 (2.638–3.577) | <0.001 | 1.188 (0.992–1.422) | 0.061 |
| T stage | ||||||
| T1 | 139,529 (56.8) | 1053 (11.8) | 1 (Reference) | NA | 1 (Reference) | NA |
| T2 | 69,406 (28.2) | 2306 (25.9) | 3.278 (3.035–3.540) | <0.001 | 1.098 (0.964–1.250) | 0.16 |
| T3 | 14,341 (5.8) | 1166 (13.1) | 6.766 (6.175–7.413) | <0.001 | 1.087 (0.937–1.262) | 0.271 |
| T4 | 10,447 (4.3) | 2519 (28.3) | 22.112 (20.310–24.073) | <0.001 | 1.183 (1.038–1.349) | 0.012 |
| Unknown | 11,984 (4.9) | 1857 (20.9) | 12.827 (11.632–14.145) | <0.001 | 1.050 (0.908–1.214) | 0.512 |
| N stage | ||||||
| N0 | 163,122 (66.4) | 2190 (24.6) | 1 (Reference) | NA | 1 (Reference) | NA |
| N1 | 54,522 (22.2) | 3569 (40.1) | 2.765 (2.605–2.934) | <0.001 | 1.132 (1.027–1.249) | 0.013 |
| N2 | 12,630 (5.2) | 899 (10.1) | 2.238 (2.050–2.443) | <0.001 | 0.995 (0.865–1.144) | 0.941 |
| N3 | 8210 (3.3) | 1078 (12.1) | 3.564 (3.268–3.887) | <0.001 | 0.862 (0.759–0.980) | 0.024 |
| Unknown | 7223 (2.9) | 1165 (13.1) | 5.070 (4.593–5.596) | <0.001 | 0.883 (0.777–1.004) | 0.057 |
| Subtype | ||||||
| HR+/HER2− | 164,630 (67) | 5128 (57.6) | 1 (Reference) | NA | 1 (Reference) | NA |
| HR+/HER2+ | 22,798 (9.3) | 1150 (12.9) | 1.105 (1.027–1.187) | 0.007 | 0.711 (0.634–0.797) | <0.001 |
| HR−/HER2+ | 10,009 (4.1) | 452 (5.1) | 0.700 (0.628–0.780) | <0.001 | 0.354 (0.307–0.408) | <0.001 |
| TNBC | 25,965 (10.5) | 715 (8) | 0.520 (0.476–0.567) | <0.001 | 0.340 (0.302–0.382) | <0.001 |
| Unknown | 22,305 (9.1) | 1456 (16.4) | 0.825 (0.763–0.892) | <0.001 | 0.543 (0.487–0.604) | <0.001 |
Notes:
a
Patients with unknown information of bone metastasis were excluded from the entire cohort and the MBC cohort in the logistic model (n=5064 and n=446; respectively).
b
Other including American Indian/Alaska Native, Asian/Pacific Islander.
Abbreviations: HER2, human epidermal growth factor receptor 2; HR, hormone receptor; MBC, metastatic breast cancer; OR, odds ratio; TNBC, triple-negative breast cancer; NA, not available.