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. Author manuscript; available in PMC: 2018 Feb 13.
Published in final edited form as: Prog Brain Res. 2016 Jun 10;227:159–186. doi: 10.1016/bs.pbr.2016.04.026

FIG. 6.

FIG. 6

Medial temporal lobe structure and connectivity predict children’s math learning. (A) Gray matter volume in hippocampus correlates with improvement in arithmetic performance in response to 8 weeks of one-to-one math tutoring. (B) Intrinsic functional connectivity of the hippocampus correlates with improvement in arithmetic performance in response to 8 weeks of one-to-one math tutoring. Performance gains were predicted by hippocampal connectivity with the left dorsolateral prefrontal cortex (L DLPFC), left ventrolateral prefrontal cortex (L VLPFC), right supplementary motor area (R SMA), left basal ganglia (L BG), and right middle temporal gyrus (R MTG). Composite 3D view of connectivity network is shown in the central panel with the right hippocampus seed ROI highlighted in red (gray in the print version) and voxels showing peak connectivity with the hippocampus highlighted in green (light gray in the print version). Surrounding panels show brain areas correlated with performance gains with tutoring. Scatter plots in each panel are based on voxels showing peak connectivity.

Adapted from Supekar, K., Swigart, A.G., Tenison, C., Jolles, D.D., Rosenberg-Lee, M., Fuchs, L., Menon, V., 2013. Neural predictors of individual differences in response to math tutoring in primary-grade school children. Proc. Natl. Acad. Sci. U.S.A. 110, 8230–8235.