Table 1.
Median CD4 cell count at ART initiation and other clinical, demographic and drug-use characteristics, stratified by calendar year of ART initiation among 355 illicit drug users in Vancouver, Canada, 2005 – 2013 (n=355)
| Characteristic | 2005 n (%) |
2006 n (%) |
2007 n (%) |
2008 n (%) |
2009 n (%) |
2010 n (%) |
2011 n (%) |
2012 n (%) |
2013 n (%) |
p-value1 |
|---|---|---|---|---|---|---|---|---|---|---|
| CD4 cell count (per 100 cells/mL) | ||||||||||
| Median (IQR) | 1.30 (0.60 – 2.05) | 1.60 (1.05 – 2.05) | 1.90 (1.25 – 2.45) | 1.90 (0.95 – 2.75) | 2.40 (1.60 – 2.30) | 3.10 (2.40 – 3.80) | 3.80 (2.10 – 5.10) | 3.10 (1.80 – 4.30) | 3.30 (2.05 – 4.30) | < 0.001 |
| Age | ||||||||||
| Median (IQR) | 39 (31 – 47) | 40 (37 – 47) | 41 (34 – 46) | 43 (34 – 48) | 42 (33 – 46) | 42 (36 – 48) | 36 (31 – 42) | 42 (33 – 47) | 45 (38 – 54) | 0.801 |
| Gender | ||||||||||
| Non-male | 15 (43) | 12 (30) | 24 (38) | 16 (34) | 12 (23) | 14 (39) | 20 (43) | 10 (43) | 7 (58) | |
| Male | 20 (57) | 28 (70) | 39 (62) | 31 (66) | 41 (77) | 22 (61) | 26 (57) | 13 (57) | 5 (42) | 0.299 |
| Caucasian ancestry | ||||||||||
| No | 15 (43) | 15 (38) | 28 (44) | 22 (47) | 21 (40) | 13 (36) | 21 (46) | 14 (61) | 6 (50) | |
| Yes | 20 (57) | 25 (62) | 35 (56) | 25 (53) | 32 (60) | 23 (64) | 25 (54) | 9 (39) | 6 (50) | 0.331 |
| DTES2 dispensation | ||||||||||
| No | 25 (71) | 25 (62) | 43 (68) | 31 (66) | 37 (70) | 25 (69) | 37 (80) | 15 (65) | 11 (92) | |
| Yes | 10 (29) | 15 (38) | 20 (32) | 16 (34) | 16 (30) | 11 (31) | 9 (20) | 8 (35) | 1 (8) | 0.144 |
| Years of illicit drug use | ||||||||||
| Median (IQR) | 13 (8 – 20) | 17 (10 – 21) | 18 (11 – 26) | 14 (6 – 22) | 16 (6 – 23) | 16 (3 – 26) | 16 (10 – 19) | 11 (8 – 20) | 20 (14 – 28) | 0.823 |
| HIV-1 RNA (per log10 copies/mL plasma) | ||||||||||
| Median (IQR) | 5.0 (4.6 – 5.0) | 5.0 (4.7 – 5.0) | 4.8 (4.3 – 5.0) | 4.8 (4.2 – 5.0) | 4.5 (4.1 – 5.0) | 4.5 (4.0 – 5.1) | 4.4 (3.7 – 4.9) | 4.6 (4.2 – 4.8) | 4.2 (3.2 – 4.8) | < 0.001 |
| PI3 in first regimen | ||||||||||
| No | 8 (29) | 11 (33) | 9 (20) | 10 (26) | 12 (35) | 4 (17) | 4 (11) | 3 (16) | 0 (0) | |
| Yes | 20 (70) | 22 (67) | 36 (80) | 28 (74) | 22 (65) | 20 (83) | 31 (89) | 16 (84) | 8 (100) | 0.255 |
| ADI4 | ||||||||||
| Never | 27 (77) | 36 (90) | 54 (86) | 38 (81) | 45 (85) | 33 (92) | 41 (89) | 21 (91) | 12 (100) | |
| Ever | 8 (23) | 4 (10) | 9 (14) | 9 (19) | 8 (15) | 3 (8) | 5 (11) | 2 (9) | 0 (0) | 0.062 |
1
Test for trend
2
Downtown Eastside
3
Protease Inhibitor
4
AIDS-defining illness