Table 3.

Bivariable and multivariable Cox proportional hazards analyses of factors associated with time to plasma HIV-1 RNA viral load < 50 copies/mL in the first year following ART initiation among 355 illicit drug users in Vancouver, Canada, 2005 – 2013

Characteristic	HR1	95% CI2	p-value	AHR3,6	95% CI2	p-value
CD4 cell count 4
Per 100 cells/mL	1.20	1.12 – 1.28	< 0.001	1.13	1.05 – 1.22	< 0.001
Age at ART initiation4
Per year older	1.01	0.99 – 1.03	0.198
Gender4
Non-male	1.00
Male	1.05	0.78 – 1.42	0.751
Caucasian ancestry4
No	1.00
Yes	1.09	0.81 – 1.46	0.575
DTES dispensation4
No	1.00
Yes	0.86	0.62 – 1.19	0.359
Years since illicit drug use initiation4
Per year increase	1.00	0.99 – 1.02	0.532
HIV-1 RNA viral load4
Per log10 increase	0.68	0.58 – 0.79	< 0.001	0.51	0.37 – 0.71	< 0.001
AIDS-defining illness4
Never	1.00
Ever	0.52	0.31 – 0.88	0.014	0.60	0.35 – 1.02	0.060
PI in first regimen4
No	1.00
Yes	0.92	0.69 – 1.23	0.571
Year of ART initiation4
Per year increase	1.35	1.27 – 1.44	< 0.001

¹Hazard Ratio

²95% Confidence Interval

³Adjusted Hazard Ratio

⁴Baseline at ART initiation

⁵First year after ART initiation

⁶Multivariable model also included interaction term for time by HIV-1 RNA viral load at ART initiation