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. 2018 Jan 15;10(1):100–114. doi: 10.18632/aging.101362

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Copyright © 2018 Sun et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The influence of senescence on expression and processing of APP in human BMECs. Human BMECs were passaged 5 and 15 times. Cell lysates were subjected to Western blot. Protein levels of (A) APP, (B) ADAM10, (C) ADAM17, (D) ADAM9 and (F) BACE1 were measured, n=6-9. Cells were incubated in 1.5ml EGM2 for 24h. Conditioned media were collected for measuring sAPPα (E, n=13) and Aβ40 (G, n=15) via commercially available ELISA kits respectively. Data are presented as mean±SEM, *P<0.05, compared to P5.