Table 4. Differences at baseline and differences of change of participants with vs without a priori defined significant gait decline (>0.1 m/s per annum).

Baseline age 73			p	Changes		p
	Decline N =108 (24.4%)	No Decline N =335 (75.6%)		Decline	No Decline
Sex/male, N (%)	68 (62.96)	176 (52.54)	0.060	NA	NA
Age	72.23 (0.90)	72.63 (1.07)	0.004	3.82 (0.11)	3.79 (0.16)	0.015
Physical factors
Height	168.40 (12.75)	166.49 (13.60)	0.131	-0.50 (1.28)	-0.50 (1.25)	0.552
Grip Strength	30.50 (15.88)	29.00 (15.50)	0.394	-1.75 (5.50)	-1.00 (4.38)	0.293
Leg cramp, N(%)	39 (36.11)	130 (38.81)	0.650	21 (19.44)	59 (17.61)	0.448
Arthritis, N(%)	51 (47.22)	155 (46.27)	0.912	8 (7.41)	32 (9.55)	0.219
Risk factors
Smoking, N(%)	9 (8.33)	21 (6.29)	0.615
HBP, N(%)	49 (45.37)	170 (50.75)	0.376	7 (6.48)	32 (9.55)	0.602
Diabetes, N(%)	12 (11.11)	30 (8.96)	0.571	5 (4.63)	9 (2.69)	0.517
HChol, N(%)	45 (41.67)	139 (41.50)	0.975	15 (13.89)	33 (9.85)	0.481
BMI	27.53 (4.96)	27.19 (4.84)	0.449	0.09 (1.39)	0.02 (1.72)	0.387
Gait and Balance
6 meter walk time (sec)	3.60 (0.83)	4.33 (0.99)	<0.001	1.59 (0.87)	0.23 (0.69)	<0.001
Gait speed (m/sec)	1.72 (0.52)	1.45 (0.33)	<0.001	-0.46 (0.22)	-0.03 (0.27)	<0.001
Chair-stands(sec)	12.07 (5.02)	13.04 (4.62)	0.051	0.29 (4.52)	-0.27 (4.29)	0.002
Standing score=4, N(%)	96 (88.9)	295 (88.1)	0.725	5.56% decrease	4.81% decrease (N=333)	0.685
MRI-markers
Brain Volume*	68.94 (2.79)	69.24 (2.76)	0.173	-1.46 (0.02)	-1.07 (0.01)	0.003
WMH Volume*	0.55 (0.86)	0.51 (0.73)	0.454	0.26 (0.01)	0.17 (0.01)	0.024

Sample characteristics are presented as median and interquartile range (IQR in brackets) if not otherwise specified. Changes for nominal variables are indicated as number of additional participants with a present physical or risk factor at follow-up.

HBP = high blood pressure, HChol = high cholesterol, *Normalized by intracranial volume in %