Table 2.

Association of statin use at AA initiation and AA duration in DFCI and JHU cohorts

	N	N stopped	Median AA duration	HR and 95% CI (univariate)	P	HR and 95% CI (multivariable)	P
DFCI Cohort
Statin use at AA initiation					0.14		* 0.18 ** 0.14
No statin use	132	98	9.2	1 (reference)		1 (reference)
With statin	92	62	14.2	0.79 (0.57, 1.09)		* 0.81 (0.58, 1.11) ** 0.79 (0.57, 1.09)
JHU Cohort
Statin use at AA initiation					0.38		* 0.52 ** 0.49
No statin use	143	128	8.3	1 (reference)		1 (reference)
With statin	122	104	8.0	0.89 (0.69, 1.15)		* 0.92 (0.70, 1.20) ** 0.91 (0.70, 1.19)

^*Adjusting for prior use of enzalutamide, docetaxel, and sites of metastases

^**Adjusting for prior use of enzalutamide and docetaxel