Figure 9. Cisplatin-induced DNA-protein crosslinks accumulate at elevated levels in NER-deficient Chinese hamster cells.
Wild type (V79, dark bar) and NER-deficient (V-H1, light bar) Chinese hamster cells were exposed to 100 μM cisplatin for one hour in serum-free media, and levels of chromosomal DPCs determined. The graph depicts mean percent of protein-crosslinked DNA (calculated as described in the Methods), ± SEM, N=3, *P < 0.05.