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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Transl Res. 2017 Nov 3;192:30–45. doi: 10.1016/j.trsl.2017.10.007

Figure 2.

Figure 2

(A) Single-kidney BOLD-MRI illustrating hypoxic regions (yellow-red). R2* in the cortex and medulla increased in GOF-AD by 3-months on diet, and in GOF-ND by 6 months (n=7/group). (B) MRE showed in-vivo elevated renal medullary stiffness (yellow-red) at 6-month in both GOF groups (n=5/group). (C) Representative three-dimensional micro-CT images of kidney segments and quantification of renal microvascular spatial density and tortuosity, showing an increase in the microvascular density in GOF groups unchanged tortuosity. *p<0.05 vs. WT; †p<0.05 vs. GOF-ND.