Table 3.
HFpEF (n = 51,162) | HFrEF (n = 41,340) | Unspecified HF (n = 58,457) | |
---|---|---|---|
HF-related medications (%) | |||
ACEIs/ARBs* | 47.2 | 55.7 | 47.6 |
ACEIs | 32.8 | 43.2 | 34.2 |
ARBs | 16.3 | 14.7 | 15.2 |
EBBBs† | 33.0 | 52.7 | 35.3 |
Aldosterone antagonists | 10.6 | 17.4 | 11.0 |
Nitrates | 19.8 | 24.3 | 18.2 |
Hydralazine | 9.4 | 8.7 | 6.8 |
Loop diuretics | 71.3 | 72.8 | 65.3 |
Thiazide diuretics | 14.0 | 12.3 | 12.0 |
Potassium-sparing diuretics | 2.1 | 1.5 | 1.7 |
Digoxin | 12.9 | 20.4 | 15.5 |
Other cardiac medications (%) | |||
Non-evidence-based β-blockers | 38.1 | 28.2 | 31.9 |
Antiarrhythmic agents | 9.0 | 14.1 | 9.3 |
Calcium channel blockers | 39.1 | 22.8 | 30.7 |
Dihydropyridine | 25.3 | 15.3 | 20.5 |
Diltiazem | 12.1 | 6.7 | 8.9 |
Verapamil | 1.7 | 0.8 | 1.3 |
Renin inhibitors | 0.5 | 0.3 | 0.4 |
Anticoagulants | 29.8 | 32.1 | 28.6 |
Statins | 48.8 | 54.2 | 46.9 |
HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; EBBB, evidence-based β-blocker.
5% of patients had claims for both ACEIs and ARBs and were counted in both ACEI and ARB subcategories, so the sum of ACEI/ARB is not equal the sum of ACEI and ARB subcategories;
Includes bisoprolol, carvedilol, and metoprolol succinate extended release.