Figure 4. Expression of cGMP signaling components in intestinal polyps from Apc^Min/+ mice.

A, The expression of cGMP generators was measured by RT-qPCR in non-neoplastic tissue and untreated and treated polyps from Apc^Min/+ mice (Control, Ctrl; Sildenafil, Sild). B, The expression of cGMP effectors were measured by real-time qPCR in non-polyp tissue and polyps from untreated and treated Apc^Min/+ mice. C, The expression of phosphodiesterases with activity toward cGMP were measured by RT-qPCR in non-polyp tissue and untreated and treated polyps from Apc^Min/+ mice. n= 6 mice; Error bars show SEM, and the p-values are from a One-way ANOVA and Tukey’s post hoc analysis.