Table 1.
Patient-Reported Outcomes by Average BPI 24-hour Pain Score of Mild, Moderate, and Severe for MSKCC Pain Registry Patients
| Patient-Reported Outcome | Mild (1–4) Mean score (SD) | Moderate (5–6) Mean score (SD) | Severe (7–10) Mean score (SD) | Significant Differences |
|---|---|---|---|---|
| Pain Intensity and Pain Relief (BPI) | N=374 (24.6%) | N=632 (41.5%) | N=517 (33.9%) | |
| Average Pain last 24 hrs. | 3.2C (0.8) | 5.5B (0.5) | 7.8A (0.9) | A>B>C* p<.0001 |
| Average Worst Pain last 24 hrs. | 5.2C (2.0) | 7.1B (1.4) | 8.4A (1.2) | A>B>C* p<.0001 |
| Average Least pain last 24 hrs. | 1.9C (1.4) | 3.6B (1.6) | 6.0A (2.1) | A>B>C* p<.0001 |
| Average Percent Relief last 24 hrs. | 61.0C (26.7) | 53.7B (22.0) | 45.5A (24.5) | A<B<C* p<.0001 |
| Patients Pain Interference (BPI) | N=368 (24.6%) | N=624 (41.6%) | N=506 (33.8%) | |
| Average Pain Interference score | 3.9C (2.2) | 5.6B (1.9) | 7.0A (1.8) | A>B>C* p<.0001 |
| General Activity | 4.2C (2.6) | 6.1B (2.2) | 7.5A (1.9) | A>B>C* p<.0001 |
| Mood | 3.8C (2.4) | 5.6B (2.4) | 7.0A (2.2) | A>B>C* p<.0001 |
| Walking Ability | 3.5C (2.9) | 5.2B (2.7) | 6.4A (2.9) | A>B>C* p<.0001 |
| Normal Work | 4.4C (2.8) | 6.1B (2.5) | 7.4A (2.2) | A>B>C* p<.0001 |
| Relation with Other People | 2.8C (2.4) | 4.3B (2.6) | 5.7A (2.7) | A>B>C* p<.0001 |
| Sleep | 3.7 C (2.6) | 5.5 B (2.5) | 6.9A (2.6) | A>B>C* p<.0001 |
| Enjoyment of Life | 4.6C (2.7) | 6.4B (2.3) | 7.7A (2.2) | A>B>C* p<.0001 |
| CMSAS Physical Symptoms in past 7 days | N=368 (24.8%) | N=618 (41.7%) | N=496 (33.5%) | |
| Average CMSAS Physical score | 1.4C (0.7) | 1.6B (0.7) | 1.9A (0.7) | A>B>C* p<.0001 |
| Lack of energy | 2.0C (1.2) | 2.3B (1.1) | 2.6A (1.1) | A>B>C* p<.0001 |
| Lack of Appetite | 1.1B (1.2) | 1.2B (1.2) | 1.5A (1.3) | A>B* p<.0001 |
| Pain | 2.4C (0.9) | 3.0B (0.7) | 3.5A (0.6) | A>B>C* p<.0001 |
| Dry Mouth | 1.0C (1.1) | 1.2B (1.2) | 1.5A (1.4) | A>B>C* p<.0001 |
| Weight Loss | 0.6B (1.1) | 0.7B (1.0) | 1.0A (1.3) | A>B* p<.0001 |
| Feeling Drowsy | 1.3B (1.2) | 1.4B,A (1.2) | 1.6A (1.3) | A>B* p=0.025 |
| Shortness of Breath | 0.7B (1.1) | 0.7B (1.0) | 0.9A (1.2) | A>B* p=0.003 |
| Constipation | 1.0B (1.2) | 1.2A (1.3) | 1.3A (1.3) | A>B* p=0.018 |
| Difficulty Sleeping | 1.4C (1.2) | 1.9B (1.3) | 2.3A (1.3) | A>B>C* p<.0001 |
| Nausea | 0.5C (0.9) | 0.7B (1.0) | 0.9A (1.1) | A>B>C* p<.0001 |
| CMSAS Psychological Symptoms in past 7 days | N=363 (24.6%) | N=617 (41.8%) | N=497 (33.6%) | |
| Average CMSAS Psychological score | 1.3C (1.0) | 1.6B (1.1) | 2.0A (1.2) | A>B>C* p<.0001 |
| Worrying | 1.6C (1.2) | 1.9B (1.3) | 2.3A (1.3) | A>B>C* p<.0001 |
| Feeling Sad | 1.2C (1.1) | 1.6B (1.2) | 1.9A (1.3) | A>B>C* p<.0001 |
| Feeling Nervous | 1.1C (1.1) | 1.4B (1.2) | 1.8A (1.3) | A>B>C* p<.0001 |
| Patients Health State and | N=360 (24.8%) | N=611 (42.1%) | N=481 (33.1%) | |
| Health State VAS 100 to 0 (best to worst) | 58.9C (19.4) | 55.4B (17.4) | 48.7A (20.1) | A<B<C* p<.0001 |
| EQ-5D Health State Index, 1.1 to 0 (best to worst) | 0.7C (0.2) | 0.6B (0.2) | 0.5A (0.2) | A<B<C* p<.0001 |
| Number of Unique Pain Locations | N=374 (24.6%) | N=632 (41.5%) | N=517 (33.9%) | |
| Average Number of Unique Pain Locations | 4.4C (3.5) | 6.0B (4.6) | 6.9A (5.2) | A>B>C* p<.0001 |
| Percent of Patients Identifying Site as Worst Pain Locations | Percent of Patients | Percent of Patients | Percent of Patients | |
| Abdomen-Chest | 26.2 | 19.9 | 15.9 | p<0.001** |
| Back | 21.1 | 21.2 | 23.6 | NS |
| Buttock | 5.6 | 4.7 | 5.6 | NS |
| Extremities | 15.4 | 21.5 | 16.3 | NS |
| Face-Head-Neck | 8.6 | 10.3 | 7.4 | NS |
| Hip | 5.3 | 6.0 | 5.6 | NS |
| Missing | 17.6 | 16.5 | 25.7 | NS |
*
Probability based on Analysis of Variance test and Duncan’s Multiple Range test differences
**
Cochran-Armitage Trend Test; NS=not significant