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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Stroke Cerebrovasc Dis. 2017 Oct 31;27(3):555–562. doi: 10.1016/j.jstrokecerebrovasdis.2017.09.048

Table 2.

Predictors of abnormal cell counts at day 3 after stroke.

WBCs >10,000/μL PMNs >7,000/μL Lymphocytes <1,000/μL Monocytes >800/μL Eosinophils <50/μL
Univariate OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P
NIHSS (per point) 1.12 (1.06–1.18) <0.001 1.13 (1.07–1.20) <0.001 1.08 (1.03–1.15) 0.004 1.15 (1.09–1.22) <0.001 1.15 (1.08–1.22) <0.001
Total infarct volume (per 10 cc) 1.05 (1.01, 1.08) 0.01 1.01 (1.00, 1.01) <0.001 1.08 (1.03, 1.13) 0.001 1.10 (1.05, 1.16) <0.001 1.12 (1.06, 1.18) <0.001
Cortisol (per μg/dL) 1.15 (1.07–1.24) <0.001 1.16 (1.08–1.26) <0.001 1.14 (1.05–1.23) 0.001 1.14 (1.06–1.23) <0.001 1.16 (1.07–1.26) <0.001
ACTH (per pg/mL) 1.01 (0.99–1.04) NS 1.00 (0.98–1.03) NS 1.02 (0.99–1.04) NS 1.01 (0.99–1.03) NS 1.01 (0.98–1.03) NS
IL-6 (per pg/mL) 1.03 (1.00–1.06) 0.02 1.03 (1.00–1.05) 0.02 1.02 (1.00–1.04) 0.03 1.04 (1.01–1.08) 0.02 1.04 (1.01–1.07) 0.01
Metanephrines (per pg/mL) 0.99 (0.95–1.04) NS 0.92 (0.86–0.0.99) 0.02 1.00 (0.94–1.06) NS 1.00 (0.96–1.04) NS 0.99 (0.94, 1.05) NS
Multivariate – Model 1 OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P
NIHSS (per point) 1.09 (1.00–1.18) 0.04 1.14 (1.03, 1.26) 0.009 1.04 (0.94–1.15) NS 1.17 (1.07–1.29) <0.001 1.14 (1.04, 1.25) 0.004
Cortisol (per μg/dL) 1.10 (1.00–1.22) 0.05 1.17 (1.03, 1.32) 0.02 1.18 (1.05–1.34) 0.007 1.05 (0.94–1.17) NS 1.05 (0.94, 1.18) NS
IL-6 1.00 (0.97–1.03) NS 0.98 (0.95–1.02) NS 0.99 (0.96–1.02) NS 0.99 (0.96–1.03) NS 1.01 (0.97–1.05) NS
Metanephrines (per pg/mL) 1.01 (0.95–1.06) NS 0.92 (0.84–1.02) NS 1.01 (0.94–1.08) NS 1.02 (0.96–1.08) NS 1.00 (0.94, 1.07) NS
Multivariate – Model 2 OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P
Total infarct volume 1.00 (0.94, 1.06) NS 1.04 (0.98, 1.11) NS 1.06 (1.00, 1.13) <0.05 1.09 (1.02, 1.16) 0.010 1.12 (1.05, 1.21) 0.001
Cortisol (per μg/dL) 1.14 (1.04–1.27) 0.08 1.20 (1.06, 1.35) 0.004 1.17 (1.03–1.32) 0.01 1.07 (0.97, 1.19) NS 1.05 (0.94, 1.18) NS
IL-6 1.01 (0.98–1.03) NS 1.00 (0.97–1.03) NS 0.99 (0.96–1.02) NS 1.01 (0.98–1.05) NS 1.02 (0.99–1.06) NS
Metanephrines (per pg/mL) 0.99 (0.94–1.05) NS 0.90 (0.81–1.00) 0.04 1.01 (0.94–1.08) NS 1.01 (0.96–1.06) NS 1.00 (0.94, 1.07) NS
Multivariate – Model 3 OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P
NIHSS (per point) 1.14 (1.03, 1.26) 0.01 1.16 (1.03, 1.32) 0.02 0.91 (0.74, 1.11) NS 1.17 (1.05, 1.31) 0.006 1.03 (0.89, 1.19) NS
Total infarct volume (per 10 cc) 0.94 (0.87, 1.02) NS 0.98 (0.90, 1.06) NS 1.11 (0.98, 1.26) 0.09 1.00 (0.93, 1.08) NS 1.10 (1.00, 1.23) 0.06
Cortisol (per μg/dL) 1.11 (1.01–1.24) 0.03 1.17 (1.03, 1.32) 0.01 1.19 (1.04–1.35) 0.009 1.05 (0.95, 1.18) NS 1.05 (0.93, 1.18) NS
IL-6 1.00 (0.97–1.03) NS 0.98 (0.95–1.02) NS 1.00 (0.96–1.05) NS 0.99 (0.96–1.03) NS 1.02 (0.98–1.06) NS
Metanephrines (per pg/mL) 1.00 (0.95–1.06) NS 0.93 (0.84–1.02) NS 1.00 (0.93–1.08) NS 1.02 (0.93, 1.07) NS 1.00 (0.94, 1.07) NS
Multivariate – Model 4 OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P
Cortisol (per μg/dL) 1.15 (1.04–1.26) 0.005 1.22 (1.08–1.37) 0.001 1.20 (1.07–1.35) 0.002 1.10 (1.01–1.22) 0.03 1.10 (1.00–1.22) 0.06
IL-6 1.01 (0.98–1.04) NS 1.00 (0.97–1.03) NS 0.99 (0.96–1.02) NS 1.02 (0.98–1.05) NS 1.03 (0.99–1.06) NS
Metanephrines (per pg/mL) 1.00 (0.94–1.05) NS 0.89 (0.81–0.99) 0.03 1.00 (0.93–1.07) NS 1.00 (0.95–1.05) NS 0.98 (0.92–1.05) NS

OR=odds ratio, CI=confidence interval, NIHSS=National Institutes of Health Stroke Scale, NS=not significant (P>0.10)