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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Exp Eye Res. 2017 Nov 6;167:56–90. doi: 10.1016/j.exer.2017.10.023

Figure 12.

Figure 12

S334ter-5 rats - Light micrographs of the outer retina at ages ranging from P6 (A) to P90 (G). Ages given on the micrographs. All micrographs are taken from the superior posterior to equatorial regions of the eyes, except H, which is from the inferior posterior hemisphere in the same retinal section as E. (A) Developing ONL at P6, which is indistinguishable from that of normal controls. (B–E) The IPS contains an increasing number of displaced immature PRs (d), some in clusters (D, E), but the ONL does not show many pyknotic nuclei (arrows) until P12 (D). A pyknotic nucleus is shown internalized within the RPE (D). Coincident with the appearance of pyknotic nuclei at P12 and P15 is the appearance of invading presumptive microglia into the ONL (Figs. 12D, E; arrowheads). Very short, disorganized PR OSs (os) are shown at ages from P10-P30 (C–F, H). The inferior posterior hemisphere (H) at P15 is thicker than superior posterior in the same retina (E). Magnification bar = 20 μm.