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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Exp Eye Res. 2017 Nov 6;167:56–90. doi: 10.1016/j.exer.2017.10.023

Figure 6.

Figure 6

WT SD rats - Light micrographs of the outer retina at different ages ranging from neonatal P6 (A) to one year of age (I) for comparison with the rhodopsin mutants. Ages in postnatal days (P), given on the micrographs. All micrographs are taken from the superior posterior or superior equatorial regions of the eyes. PR OSs (OS) begin to be elaborated at P8 (B), and they elongate and become more organized (D, E) until they reach the adult length by about P30 (F). The outer nuclear layer (ONL) comprises approximately 98.5% rod PR nuclei and 1.5% cone (c) nuclei that are slightly larger than those of rods. During the postnatal development, the PR nuclei have a spotty chromatin appearance until about P21 (E) to P30 (F). Some naturally occurring cell death is seen as pyknotic nuclei (arrow). The RPE (RPE) contains ingested ROS tips, known as phagosomes (p). As the retina ages, the retina thins slowly, particularly after P30 (F–I), as shown in the ONL thickness in Fig. 1. INL, inner nuclear layer; IPL, inner plexiform layer. Note: The layer designations apply to the same labels in Figs. 7–14, below. Magnification bar = 20 μm.