Table 4.
Ages of retinas examined by electron microscopy and incidence of extracellular vesicles in the interphotoreceptor space
| Line | P8 | P9 | P10 | P12 | P14-15 | P20-22 | P30-32 | P60 | P120 | P240-365 |
|---|---|---|---|---|---|---|---|---|---|---|
| SD | 0 | – | 0 | 0 | 0 | 0 | – | – | – | – |
| P23H-1 | – | – | 0 | 0 | – | – | 0 | – | 0 | – |
| P23H-3 | – | – | – | 0 | 0 | 0 | – | – | – | 0 |
| P23H-2 | – | – | – | – | – | – | 0 | – | – | 0 |
| S334ter-7 | 0 | 0 | – | – | 0 | – | – | – | – | – |
| S334ter-3 | 0 | – | 0 | 0 | – | – | 0 | – | – | – |
| S334ter-5 | – | – | – | 0 | ++ | – | + | – | – | – |
| S334ter-4 | – | – | – | 0 | + | +++ | ++ | +, 0* | 0 | – |
| S334ter-9 | – | – | – | – | 0 | 0 | 0 | – | – | – |
| S334ter-9 (Homoz.) | – | – | – | – | – | – | +++ | – | – | – |
–, not examined by electron microscopy.
For each age studied, the observations are based on examination of 6–15 electron micrographs.
Ages examined and incidence of vesicles in the interphotoreceptor space: 0, none; +, few vesicles (4–7/mμ2), approximately 1/3 the maximal density; ++, significant number of vesicles (8–11/mμ2), approximately 2/3 the maximal density; +++, many vesicles (12–20/mμ2), maximal density (e.g., S334ter-4 at P21, Figs. V1B and E; S334ter-9 homozygote at P32, Figs. V2B and D).
Where 3–4 rows of photoreceptor nuclei existed, a few vesicles were present between the inner segments; none were found where only 1–2 rows of photoreceptor nuclei were present.