Figure 5.

Resistant subclones in clinically detectable simulated tumors. (A) Probability density functions for the log₁₀ sizes of therapeutically resistant subclones within in the primary simulated tumors. (B) Number of independent resistant subclones in each simulated primary tumor. Each bar represents a tumor. The area in light gray represents those simulated tumors with no resistant subclones, which should be curable. For each set of parameter values used, N is the number of tumors generated by the model. It is assumed that a resistant mutation occurs at a rate of 1 × 10⁻⁸ per cell division. Resistant mutations are assumed not to affect fitness.