. Author manuscript; available in PMC: 2019 Mar 1.

Published in final edited form as: Genet Epidemiol. 2017 Dec 10;42(2):134–145. doi: 10.1002/gepi.22105

Table 2.

Simulation 2: Comparison of empirical powers (based on corrected critical values) for two independent studies at level α = 10⁻⁴. Power is estimated based on 10⁴ non-null datasets. For a given association scenario, the method with highest power is bold-faced and the method with lowest power is italicized.

Study type	No. of traits associated	Meta-analysis method

		S_Hom	S_Het	minP	aSPU	metaMANOVA	metaUSAT
	1	0.999	0.923	0.034	0.009	1.000	1.000
Homogeneous	2	0.000	0.111	0.046	0.082	0.151	0.133
	3	0.306	0.254	0.078	0.364	0.250	0.285
	4	0.009	0.725	0.100	0.387	0.665	0.632

	1	0.357	0.661	0.019	0.004	0.995	0.992
Heterogeneous	2	0.000	0.016	0.024	0.019	0.023	0.020
	3	0.017	0.036	0.035	0.044	0.038	0.045
	4	0.001	0.194	0.050	0.068	0.159	0.141