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. 2018 Feb 13;8:2883. doi: 10.1038/s41598-018-21035-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inter- and intra-animal variability of the GluCEST MRI. Five mice were scanned at three timepoints, with second and third scan at 3^rd and 6^th day following the first scan. The GluCEST values were calculated from ROIs placed in the striatum of the brain on the MR slice. (a) Average of GluCEST contrast from the striatum of the 5 mice from each scan and (b) Average of GluCEST contrast from 3 scans in each mouse. Data are presented as Mean ± SD.