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. 2018 Feb 13;8:2899. doi: 10.1038/s41598-018-21253-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sinusoidal reconstruction of the time series integrin-FN total adhesion force. (a) Oscillatory component 1, (b) component 2 and (c) the sum of the two leading components for live VSMCs (red) and fixed VSMCs (blue). Time series adhesion data were plotted using the oscillation parameters for the first two leading components obtained from the summarized result of the SSA-FFT performed on the two group samples, respectively (n = 10). The result demonstrated the significant oscillations in the time series adhesion force for live VSMCs compared to the relative flat profile of the total adhesion force for fixed VSMCs.