Figure 6.

Model and simulation of the effects of V-ATPase and CLC7 on the lysosomal accumulation of CFZ-H⁺Cl⁻ at a higher dose. (a) V-ATPase inhibition showed a more substantial effect than CLC7 inhibition on the accumulation of CFZ-H⁺Cl⁻ at the rate of 0.1 picomol/cell/day, as reflected by the changes in the lysosomal pH, Cl⁻, and membrane potential values of the CFZ-H⁺Cl⁻ containing lysosome from that of the CFZ-H⁺Cl⁻ free lysosome. (b) V-ATPase inhibition showed a more substantial effect than CLC7 inhibition on the physiological accumulation of CFZ-H⁺Cl⁻ at the rate of 0.1 picomol/cell/day, as reflected by the changes in the lysosomal pH, Cl⁻, and membrane potential values of the CFZ-H⁺Cl⁻ containing lysosome from respective baseline physiological values. Arrow signs represent values outside of the axes plot range.