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. 2018 Feb 13;8:2953. doi: 10.1038/s41598-018-20590-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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C5aR was expressed by RGCs. Double-labeling immunohistochemistry in the control eyes showed that RGCs labeled with anti-RBPMS antibody (green fluorescence A,C) colocalized with anti-C5aR staining (red fluorescence B,C), and the DACs labeled with anti-CHAT antibody (green fluorescence E,F) did not colocalize with anti-C5aR staining (red fluorescence D,F). The anti-C5L2 labeling did not show specific staining in retina (red fluorescence G). Abbreviated symbols: RGCs, retinal ganglion cells; RBPMS, RNA-binding protein with multiple splicing; DACs, displaced amacrine cells; CHAT, choline acetyl transferase; GCL, ganglion cell layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; OS, photoreceptor outer segments.