Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
List illustrating the functions of DUBs in regulating intrinsic apoptosis.
| Name | Function |
|---|---|
| USP27 | Deubiquitination of Bim |
| USP14 | Upregulation of Bcl-xL |
| USP9x | Deubiquitination of Mcl-1 |
| USP15 | Deubiquitination and stabilization of procaspase-3 |
| USP39 | Downregulation of p21, p27, and Bax |
| USP11 | Deubiquitination and stabilization of XIAP |
