Table 5.
List exhibiting the functions of E3s involved in TNF induced NF-κB regulation.
| Name | Function |
|---|---|
| TRAF2 | K63-linked polyubiquitination of RIP1 |
| c-IAP1/2 | K63-linked polyubiquitination of RIP1 |
| A20 | K63-linked polyubiquitination of RIP1 |
| A20 | K48-linked polyubiquitination of RIP1 |
| LUBAC | M1-linked ubiquitination of NEMO |
| ARIH1 | K48-linked polyubiquitination of IκBβ |
| SCFβ-TrCP | K48-linked polyubiquitination of IκBα |
| TRAF7 | K29-linked polyubiquitination of p65 and NEMO |
| ECSSOCS1 | Polyubiquitination and degradation of p65 |
| PDLIM2 | Polyubiquitination and degradation of p65 |
| MKRN2 | Polyubiquitination and degradation of p65 |
| ING4 | Polyubiquitination and degradation of p65 |
| PPARγ | K48-linked polyubiquitination of p65 |
| HERC3 | K48-linked polyubiquitination of p65 |
| ZNF216 | Interacts with IKKγ, RIP and ZnF-AN1 domain and inhibits NF-κB activation |
| TRIM13 | Downregulation of IκBα |
| HACE1 | K63-linked polyubiquitination of TRAF2 |