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. 2018 Feb 13;8:2947. doi: 10.1038/s41598-018-21203-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of IOP and ICP modification on ganglion cell function in 3 and 18 month old rats. (A) Group average STR waveforms for young (3 month, blue traces) and older rat eyes (18 months, red traces) in response to increasing IOP at ICP of −5 and 25 mmHg. (B–D). Group average (±SEM) normalized STR amplitude for young and older eyes as a function of IOP at ICP −5 mmHg (B, 3 month n = 6, 18 month n = 7) ICP 5 mmHg (C, 3 month n = 9, 18 month n = 7) and ICP 25 mmHg (D, 3 month n = 5, 18 month n = 6). (E) All data from panels B-D combined and plotted as a function of the optic nerve pressure difference (ONPD = IOP – ICP, mmHg). Lines indicate dose response curve fits to 3 and 18 month old data.