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. 2018 Feb 13;8:2947. doi: 10.1038/s41598-018-21203-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of IOP and ICP modification on RNFL thickness in 3 and 18 month old rats. (A) Representative OCT cross-sections for a young (3 month, left panels) and an older eye (18 months, right panels) with increasing IOP at an ICP of −5 mmHg. (B–D) Group average (±SEM) normalized RNFL thickness for young and older eyes as a function of IOP at ICP −5 mmHg (B), 3 month n = 5, 18 month n = 8), ICP 5 mmHg (C, 3 month n = 5, 18 month n = 6) and ICP 25 mmHg (D, 3 month n = 5, 18 month n = 8). (E) All data from panels B–D combined and plotted as a function of ONPD (mmHg). Linear fits for 3 (y = −0.20*x + 103, r² = 0.08, P < 0.001) and 18 month age groups (y = −0.44*x + 10, r² = 0.19, P < 0.0017). (F). Relative total retinal thickness as a function of ONPD. Linear fits for 3 (y = −0.15*x + 103, r² = 0.62, P < 0.001) and 18 month age groups (y = −0.11*x + 102, r² = 0.39, P < 0.001).